Current Trends in Pharmacy and Pharmaceutical Chemistry

Online ISSN: 2582-5062

Current Trends in Pharmacy and Pharmaceutical Chemistry open access, peer-reviewed quarterly journal publishing since 2019 and is published under auspices of the Ateos Foundation of Science Education and Research, aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. With the aim of faster and better dissemination of knowledge, we will be publishing the article ‘Ahead of Print’ immediately on acceptance. In addition, the journal would more...


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Review Article


Article page

38-46


Authors Details

A.G. Nerkar*, G.S. Chakraborthy, R. D. Ukirde


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Anti-cancer agents from natural sources: A review


Review Article

Author Details : A.G. Nerkar*, G.S. Chakraborthy, R. D. Ukirde

Volume : 3, Issue : 4, Year : 2021

Article Page : 38-46

https://doi.org/10.18231/j.ctppc.2021.011



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Abstract

The natural products have played a dominant role in the treatment of human ailments. The discovery of penicillin has changed the scenario of modern medicine. With the ancient use of quinine for malaria, willow bark for pain and several other natural products used as medicines in ancient system of medicine such as Ayurveda and traditional China, the discovery of the medicines for the allopathic use from natural source has gained substantial attention. The ancient system of Ayurveda describes the used of many plants extracts being used for the treatment of cancer. Prevailing epidemiological factors have also described the use of the msediterranean diet and inclusion of fruits and vegetables to score low as risk factor for the cancers. Further the several discoveries have led to the transformation of the active constituents of the natural products from the dietary sources for the chemoprevention. Substantial trials in the development of the drugs from the marine and microbial origin have been fruitful and positive to develop safe and efficacious drugs. However, the success being very low due to unavailability of natural products in large gram amounts required for the clinical trials. The total synthesis of m any natural products from marine origin has also emerged to solve this issue and led to successful development of 4 marine drugs as anti-cancer agents. This overview reviews the anticancer drugs from the natural origin as the chemo preventive and chemotherapeutic agents. Wherever possible the details of the clinical trials have been discussed along with uses and mechanism of action.


Keywords: Antitumor drugs, Chemoprevention, Drug discovery, Natural product drug sources


How to cite : Nerkar A, Chakraborthy G, Ukirde R D, Anti-cancer agents from natural sources: A review. Curr Trends Pharm Pharm Chem 2021;3(4):38-46

Copyright © 2021 by author(s) and Curr Trends Pharm Pharm Chem. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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